Archive for the ‘Operations Management’ Category

Manufacturing Execution Systems in Drug Research and Development

Posted in Life Sciences, Operations Management on Wednesday, February 13th, 2019. No comments yet
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The U.S. Food & Drug Administration (FDA) outlines the drug development process in five steps: Discovery and development Preclinical research Clinical trials FDA review FDA post-market safety monitoring I caught up with Emerson’s Zuwei Jin whom you may recall from earlier posts on the role of automation in the drug development process. Zuwei explained to […]

Tracking Cell Therapy Chain of Identity

Posted in Life Sciences, Operations Management on Monday, November 5th, 2018. No comments yet
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Cell therapy is when: …cellular material is injected into a patient;[1] this generally means intact, living cells. For example, T cells capable of fighting cancer cells via cell-mediated immunity may be injected in the course of immunotherapy. For manufacturers in the Life Sciences industry, making these therapies poses challenges since each batch is specific to […]

Best Practice for MES-SAP interface Factory Acceptance Testing

Posted in Life Sciences, Operations Management on Monday, September 24th, 2018. No comments yet
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Author: Jonathan Lustri Almost all Life Sciences manufacturing execution system (MES) projects include an interface to SAP, the enterprise resource management system. This interface is strategic in that this is how the business and production are tied together. It allows the manufacturing floor to be integrated with the business for cost accounting, material planning, and […]

Best Practices for Implementing a Process Control Driven MES System

Posted in Life Sciences, Operations Management on Tuesday, August 21st, 2018. No comments yet
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Author: Jonathan Lustri I have previously been interviewed and written about a process control and MES [Manufacturing Execution Systems] architecture where the batch control logic within the process control system is the single procedural engine. It drives procedural logic and workflows executed by the MES system when called by the process control system. The benefit […]

Moving to Electronic Batch Records

Posted in Life Sciences, Operations Management on Wednesday, May 30th, 2018. One comment so far
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Yesterday we highlighted advancements in exception management technology for pharmaceutical and biopharmaceutical manufacturers. Exception management is one element in an electronic batch record (EBR). Other elements for the EBR which also have high data integrity requirements include equipment management, material management and batch record process flow and recipe management. In a PharmTech article, Making the […]