Tech Transfer in Drug Development Pipeline and Industry 4.0

Emerson's Zuwei Jin


Author: Zuwei Jin

Among all of the important trends in life sciences industry such as modular plants, integrated modules, out-of-box smart factory, single-use equipment, PAT, and manufacturing execution systems (MES), IIOT has been receiving high interest including among pharmaceutical and biotech manufacturers.

It is our view that the same technology advancement that makes Industry 4.0 possible will lead to a revolution in technology transfer through drug development pipeline.

Industry 4.0 is based on the Internet of Things (IoT). The central concept is around cyber-robotic system, which is virtually a fully automated enterprise enabled by automation all the way from the physical process, to equipment and operations, and out to the supply chains.

These cyber-robotic systems would cover not only production but also design, services, and research, providing complementary capabilities to work with each other. Interfaces between ‘intelligence’ and physical component are ever better defined with smart instrument standards. Clouds are serving as a storage for the data behind the ‘intelligence’. The cyber-robotic system can eventually work with each other without human intervention, leading to the promise of Industry 4.0. Continue Reading

Emerson Subject Matter Experts Getting Social

It’s a light posting week with travel to our Minneapolis area offices. We had a great session with many of the measurement experts we feature here on the blog.

Our objective is to get them more comfortably and effectively participating in our Emerson Exchange 365 community, LinkedIn, Twitter and this blog.

The goal is to have them share their areas of expertise more directly to you to help you operate your manufacturing and production facilities more safely, reliably and efficiently.

We’ll do this again next week with many of our flow measurement and industry experts, so stay tuned as more of these Emerson voices come out to share their points of view and thoughts on helping you improve the performance of your projects and operations.

Join these and many more experts in the Emerson Exchange 365 community and enjoy your weekend!

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Early Project Planning of Asset Data Standards

Capital project team members are under constant pressure to meet project deadlines and get the manufacturing or production process up and running. But how do they ensure that the capital assets installed will run reliably over time?

Efficient Plant: Data Standards Lead to Project SuccessIn an Efficient Plant article, Data Standards Lead to Project Success, Emerson’s Scott Janzen describes the critical need for early planning to develop and execute a data acquisition plan for all the assets in the plant that will require ongoing maintenance. He opens noting:

Assets begin to degrade as soon as they are in operation. If the documentation for those assets is lost in a storage room collecting dust, equipment may not receive the level of maintenance that it truly needs.

If not planned effectively up front and if asset technical data is delivered late in the project:

…assets cannot be set up until they have arrived on site, putting asset configuration on the critical path and increasing the risk of budget and schedule overruns.

Manufacturers see four benefits incorporating this data acquisition plan into the project scope: Continue Reading

How to Setup Plugged Impulse Line Diagnostics

Emerson's Megan Wiens


Let’s start the week with a nice “how-to” video, How to Configure the Rosemount 3051S Plugged Impulse Line Diagnostic. Emerson’s Megan Wiens shows how to configure the Rosemount 3051S Plugged Impulse Line Diagnostic to help prevent this plugging condition which can lead to reduced measurement accuracy, plant efficiency, and product quality.

Megan opens the video showing the Interactive Plant Environment in Emerson’s Rosemount Shakopee Minnesota facility. She shows a Rosemount 3051S transmitter with advanced diagnostics mounted in the process and a configurator tool, the AMS Trex Device Communicator. Continue Reading

Multipoint Piecewise Linearization for Coriolis Flow Meters

Yesterday, we looked at calibration of Coriolis mass flow meters in natural gas applications and mentioned piecewise linearization (PWL), but did not delve into it. Let’s do with today’s post.

Emerson's Tonya Wyatt


I found a presentation by Emerson’s Tonya Wyatt, Fine Tuning Coriolis Flow Meter Calibrations Utilizing Piece-Wise Linearization. The PWL calibration method basically looks at the flow rate at points over its operating range and applies a multi-point piecewise linear interpolation correction to the “as-found error”.

This correction is applied at selected linearization points and is equal and opposite to the average of the as-found values at the same flow rate. The correction values applied between neighboring points are determined by linear interpolation between the two points. Corrections above the highest flow rate are held constant. Also, the correction below the lowest point is based on linear interpolation to zero error at zero flow to allow the meter zero adjustment to control accurately below the flow rate at time, t (Qt). Continue Reading