The American Productivity & Quality Center (APQC), a world-leading authority in knowledge management (KM), defines KM: The application of a structured process to help information and knowledge flow to the right people at the right time so they can act more efficiently and effectively to find, understand, share, and use knowledge to create value. For […]
Pharma 4.0 is an initiative based on Industry 4.0, begun out of the International Society for Pharmaceutical Engineering Germany/Austria/Switzerland (ISPE D/A/CH) organization, which lead to the formation of: …the ISPE Pharma 4.0 special interest group (SIG) in 2017. Pharma 4.0 envisions highly efficient automated processes—which could be continuous, batch, or a hybrid of these—driven by […]
Manufacturing in the biotech industry has been undergoing many changes. An ADC Review article, Emerging Trends in Single-Use Technology in the Manufacturing of Antibody-Drug Conjugates, highlighted one of these trends: First introduced in the late 1970s in the form of disposable capsules and a range of filters, single-use technologies were revolutionized in the late 2000s […]
Digital twins provide a simulation of the manufacturing or production process as well as the automation systems which control it. Depending on the level of fidelity of the process models, this digital twin can have many uses. I caught up with Emerson’s Zuwei Jin who shared some of his thoughts around these digital twins. He […]
For pharmaceutical and biopharmaceutical manufacturers, scaling up production has typically meant large, 5000+ liter stainless steel bioreactors for the process. These require cleaning and sterilization between batches. Market demands are driving the need for more flexibility with smaller batches. Single-use technologies (SUT) are being applied to bioreactors to address these demands and reduce the cost […]
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